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Identification of a Novel Trimethoprim Resistance Gene, dfrK, in a Methicillin-Resistant Staphylococcus aureus ST398 Strain and Its Physical Linkage to the Tetracycline Resistance Gene tet(L)▿

机译：耐甲氧西林金黄色葡萄球菌ST398菌株中新的甲氧苄啶抗性基因dfrK的鉴定及其与四环素抗性基因tet（L）的物理联系

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A novel trimethoprim resistance gene, designated dfrK, was detected in close proximity to the tetracycline resistance gene tet(L) on the ca. 40-kb plasmid pKKS2187 in a porcine methicillin (meticillin)-resistant Staphylococcus aureus isolate of sequence type 398. The dfrK gene encodes a 163-amino-acid dihydrofolate reductase that differs from all so-far-known dihydrofolate reductases.

机译：在ca的四环素抗性基因tet（L）的附近，检测到一个新的甲氧苄啶抗性基因dfrK。序列类型为398的耐猪甲氧西林（美西林）金黄色葡萄球菌分离株中的40 kb质粒pKKS2187。dfrK基因编码的163个氨基酸的二氢叶酸还原酶不同于所有众所周知的二氢叶酸还原酶。

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Kadlec, Kristina; Schwarz, Stefan;
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年度 2008
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1. Identification of a novel trimethoprim resistance gene, dfrK, in a methicillin-resistant Staphylococcus aureus ST398 strain and its physical linkage to the tetracycline resistance gene tet(L). [J] . Kadlec K, Schwarz S Antimicrobial agents and chemotherapy. . 2009,第2期

机译：在耐甲氧西林的金黄色葡萄球菌ST398菌株中鉴定出新的甲氧苄啶抗性基因dfrK，并与四环素抗性基因tet（L）物理连接。
2. Identification of a plasmid-borne resistance gene cluster comprising the resistance genes erm(T), dfrK, and tet(L) in a porcine methicillin-resistant Staphylococcus aureus ST398 strain. [J] . Kadlec K, Schwarz S Antimicrobial agents and chemotherapy. . 2010,第2期

机译：在猪耐甲氧西林金黄色葡萄球菌ST398菌株中鉴定包含抗性基因erm（T），dfrK和tet（L）的质粒传播的抗性基因簇。
3. Transferable multidrug resistance plasmid carrying cfr associated with tet(L), ant(4′)-Ia, and dfrK genes from a clinical methicillin-resistant Staphylococcus aureus ST125 strain [J] . DeGopeguiE.R., JuanC., ZamoranoL., Antimicrobial agents and chemotherapy. . 2012,第4期

机译：携带与tet（L），ant（4'）-Ia和dfrK基因相关的cfr的可转移多药耐药质粒，来自临床耐甲氧西林金黄色葡萄球菌ST125菌株
4. Staphylococcus aureus Strains Isolated from Bovine Clinical Mastitis in New York State and Italy: Antibiotic-resistance Genes and Genotype Characteristics [C] . Annual Meeting of The National Mastitis Council . 2019

机译：从牛临床乳腺炎中分离的金黄色葡萄球菌菌株在纽约州和意大利：抗生素抗性基因和基因型特征
5. Influence of in vitro bacterial urokinase responsiveness on the in vivo pathogenesis of methicillin-sensitive Staphylococcus aureus and methicillin-resistant Staphylococcus aureus in mouse models. [D] . Yanke, Shawna Janine. 2000

机译：体外细菌尿激酶反应性对小鼠模型中甲氧西林敏感的金黄色葡萄球菌和耐甲氧西林的金黄色葡萄球菌的体内发病机理的影响。
6. Identification of a Novel Trimethoprim Resistance Gene dfrK in a Methicillin-Resistant Staphylococcus aureus ST398 Strain and Its Physical Linkage to the Tetracycline Resistance Gene tet(L) [O] . Kristina Kadlec, Stefan Schwarz 2009

机译：耐甲氧西林金黄色葡萄球菌ST398菌株中新的甲氧苄啶抗性基因dfrK的鉴定及其与四环素抗性基因tet（L）的物理联系
7. Identification of a Plasmid-Borne Resistance Gene Cluster Comprising the Resistance Genes erm(T), dfrK, and tet(L) in a Porcine Methicillin-Resistant Staphylococcus aureus ST398 Strain▿ [O] . Kadlec, Kristina, Schwarz, Stefan 2009

机译：鉴定包含耐甲氧西林金黄色葡萄球菌ST398菌株的抗性基因erm（T），dfrK和tet（L）的质粒抗性基因簇

Identification of a Novel Trimethoprim Resistance Gene, dfrK, in a Methicillin-Resistant Staphylococcus aureus ST398 Strain and Its Physical Linkage to the Tetracycline Resistance Gene tet(L)▿

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